Ian “IAN’ Campbell is a research technician in the Srivatsan lab. Ian graduated from the University of Washington, majoring in Molecular, Cellular, and Developmental biology. As an undergraduate, Ian worked to identify a putative floral signaling ortholog in a local eelgrass species. Ian also helped develop a machine learning model for analyzing scientific claims in primary literature, as part of a joint project between the University of Washington, the Allen Institute for AI, and the University of Maryland. In the Srivatsan lab, Ian aspires to employ microfluidics as an emerging medium to advance single-cell sequencing technologies.
This study presents a novel semi-permeable capsule (SPC) that isolates single cells while allowing selective biomolecular exchange, retaining larger biomolecules like genomic DNA while permitting smaller molecules to pass through. Using SPC-based single-cell whole genome sequencing (sc-WGS), researchers achieved high sensitivity and specificity in detecting genomic variants and successfully reconstructed cellular genealogies from cells harboring the hypermutator polymerase ε allele (POLE P286R).
