Sanjay Srivatsan is an Assistant Professor in the Basic Sciences Division of the Fred Hutch Cancer Center. He received his undergraduate training at the University of California, Berkeley in Bioengineering. Following this he did his PhD with Cole Trapnell and Jay Shendure developing new single-cell sequencing methods to interrogate development. Prior to joining the Hutch, Sanjay was a postdoc in David Baker's lab where designed proteins for use as nanoscopic stains in Cryo-ET. The lab is affiliated with the CompBio Program at the Fred Hutch, the Brotman Baty Institute and the Institute for Protein Design.
This study presents a novel semi-permeable capsule (SPC) that isolates single cells while allowing selective biomolecular exchange, retaining larger biomolecules like genomic DNA while permitting smaller molecules to pass through. Using SPC-based single-cell whole genome sequencing (sc-WGS), researchers achieved high sensitivity and specificity in detecting genomic variants and successfully reconstructed cellular genealogies from cells harboring the hypermutator polymerase ε allele (POLE P286R).
One Ignition Award went to Dr. Sanjay Srivatsan, an assistant professor in the Basic Sciences Division. Sanjay’s funded project will focus on [...]
