Yuqi Huang (he/him) is a bioinformatics analyst. Before joining the Srivatsan Lab, Yuqi graduated from Carnegie Mellon University, where he majored in computational biology. At CMU, his research focused on machine learning and graph algorithms. In the Srivatsan Lab, Yuqi aims to develop innovative computational methods for single-cell and spatial analysis.
This study presents a novel semi-permeable capsule (SPC) that isolates single cells while allowing selective biomolecular exchange, retaining larger biomolecules like genomic DNA while permitting smaller molecules to pass through. Using SPC-based single-cell whole genome sequencing (sc-WGS), researchers achieved high sensitivity and specificity in detecting genomic variants and successfully reconstructed cellular genealogies from cells harboring the hypermutator polymerase ε allele (POLE P286R).
